Palermo is one of the city's largest and most affluent neighbourhoods.

Its size and diversity have led to its division into several distinct neighbourhoods, so travellers and residents alike never run out of places to explore. Spanning Avenida Libertador from roughly Avenida Coronel Díaz all the way up to Belgrano is "classic" Palermo - the part of Palermo that has avoided being classified as anything else by real-estate mavens. This area is home to many parks (including the Botanical Gardens and the city's largest zoo) and many modern residential high-rises.

Surrounding Plaza Serrano are numerous trendy clothing and design shops, artisanal breweries, eclectic restaurants, many boliches (night-clubs).